Cardiac output in rats during the development of cardiac hypertrophy.
نویسنده
چکیده
AORTIC constriction causes an increase in heart weight and blood pressure in intact, but not in hypophysectomized rats.' 2 The cause of this lack of cardiac hypertrophy after hypophysectomy is unknown. Before some insight can be gained into the changes occurring after hypophysectomy, it seemed important to elucidate as many as possible of the hemodynamic events which precede and accompany cardiac hypertrophy in normal rats. The changes in heart weight and blood pressure that occur at different times after aortic constriction have already been described.4 In the present series of experiments we determined the cardiac output in normal rats and in rats whose aortas had been constricted for varying periods. We also made an attempt to assess the reserve force of the heart by determining the extent to which cardiac output could be raised by increasing inflow into the heart.
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عنوان ژورنال:
- Circulation research
دوره 6 2 شماره
صفحات -
تاریخ انتشار 1958